A simple and sensitive liquid chromatographyâ??quadrupole-time-of-flightâ??mass\nspectrometric (LC-QTOF-MS) assay has been developed for the evaluation of drug metabolism\nand pharmacokinetics (PK) properties of vipadenant in rat, a selective A2a receptor antagonist\nas one of the novel immune checkpoint inhibitors. A simple protein precipitation method using\nacetonitrile was used for the sample preparation and the pre-treated samples were separated by\na reverse-phase C18 column. The calibration curve was evaluated in the range of..........
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